Half century ago, American biologist James Watson and English physicist Francis Crick discovered the double helix structure of DNA in the 1950s. Today, this discovery has revolutionized our understanding about life and also provided unprecedented ways to precisely manipulate/control materials in a defined shape and size.
Our laboratory is interested in the approaches that utilize oligonucleotide or nucleic acids to assemble nanostructures, and examine their emerging applications in skin related areas such as transdermal sensing and drug delivery. These include pure oligonucleotide nanomaterials (e.g. DNA Aptamer, DNA Framework), oligonucleotide-inorganic hybrid nanomaterials (e.g. Spherical Nucleic Acids), and oligonucleotide-organic hybrid nanomaterials (e.g. peptide–oligonucleotide conjugates).