Scientific Publications (2012-present)

68) Than, K. Liang, S. H. Xu, L. Sun, H. W. Duan, F. N. Xi, C. J. Xu, P. Chen. Transdermal delivery of anti-obesity compounds to subcutaneous adipose tissue with polymeric microneedles patches. Small Methods. 2017, 1, 1700269.
67) Qingqing Miao, David C. Yeo, Chenjie Xu*, Kanyi Pu*. Near-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid, Angewandte Chemie, DOI: 10.1002/anie.201710727.
66)Momesh Moothanchery, Razina Z. Seeni, Chenjie Xu*, Manojit Pramanik*. In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy, Biomedical Optics Express, 2017, 8(12), 5483-5492.
65) Li Min Tay, Christian Wiraja, Yingnan Wu, Zheng Yang, Eng Hin Lee, Chenjie Xu*. The effect of temporal manipulation of transforming growth factor beta 3 and fibroblast growth factor 2 on the derivation of proliferative chondrocytes from mensenchymal stem cells—A study monitored by quantitative reverse transcription polymerase chain reaction and molecular beacon based nanosensors, Journal of Biomedical Materials Research Part A, 2017, doi: 10.1002/jbm.a.36286.
64) Malathi Mathiyazhakan, Christian Wiraja, Chenjie Xu*. A Concise Review of Gold Nanoparticles based Photo-responsive Liposomes for Controlled Drug Delivery, Nano-Micro Letters, (2018) 10: 10. ttps://
63) J., Pan, C., Wiraja, J., Zhao, J., Zhang, M., Li, L., Zheng*, C., Xu*. Nitric oxide nanosensors for monitoring the development of osteoarthritis in rat model, ACS Applied Materials & Interfaces, 2017.
62) H. Chang, M. Zheng, X. Yu, A. Than, R.Z. Seeni, R. Kang, J. Tian, D.P. Khanh, L. Liu, P. Chen, C. Xu, A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis, Advanced Materials, 2017,1702243.
61) Jiayin Fu, Hamizan Muhammad, Christian Wiraja, Chenjie Xu, Dongan Wang*. Improvement of endothelial progenitor outgrowth cell (EPOC)-mediated vascularization in gelatin-based hydrogels through pore size manipulation. Acta Biomaterialia, 2017.
60) X., Zhen, Y., Tao, Z., An, P., Chen, C., Xu, R.,g Chen, W., Huang, K., Pu*. Advanced Materials, 2017, accepted.
59) Xu, K.; Li, L.; Cui, M.; Han, Y.; Karahan, H.E.; Chow, V. & Xu, C.* (2017). Cold chain‐free storable hydrogel for infant‐friendly oral delivery of amoxicillin for the treatment of pneumococcal pneumonia. ACS Applied Materials & Interfaces, 9(22), 18440-18449.
58) D., Yeo, E., Balmayor, J., Schantz, C., Xu*. “Microneedle Physical Contact as a Therapeutic for Abnormal Scars”. European Journal of Medical Research, 2017, accepted.
57) Liu S, Yeo, D. C., Wiraja, C.,Tey H, Mrksich, M., Xu C*. Peptide delivery with poly(ethylene glycol) diacrylate microneedles through swelling effect. Bioengineering & Translational Medicine. 2017
56) Karahan, H.E.; Goh, K.; Wei, L.; Liu, Z.; Birer, Ö.; Dehghani, F.; Xu, C.; Wei, J.* & Chen, Y.* (2016). Bacterial physiology is a key for the antibacterial activity of graphene oxide. Nanoscale, 8(39), 17181-17189.
55) Razina Z. Seeni, Xiaojun Yu, Hao Chang, Peng Chen, Linbo Liu, Chenjie Xu*. Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin. ACS Applied Materials & Interfaces, 2017.
54) K.,  Xu, L.,  Li, M., Cui, Y., Han, K., Huseyin; V., Chow, C., Xu*. Cold-chain-free Storable Hydrogel for Infant-friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia, ACS Applied Materials & Interfaces.
53) Y., Gao, Y., Han, M., Cui, H., Tey, L., Wang, C., Xu*. ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure. Journal of Materials Chemistry B, 2017, 5, 4535 – 4541. 
52) M., Wang, J., Chen, C., Liu, J., Qiu, X., Wang, P., Chen and C., Xu*. A Graphene Quantum Dots-Hypochlorite Hybrid System for the Quantitative Fluorescent Determination of Total Antioxidant Capacity, Small, 2017.
51) M., Wang, L., Hu, C.,  Xu*. Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing. Lab on a Chip, 2017, 17(8): 1373-1387.
50) Wang, Lifeng; Xu, Keming; Hou, Xiaochun; Han, Yiyuan; Liu, Shiying; Wiraja, Christian; Yang, Cangjie; Yang, Jun; Wang, Mingfeng; Dong, Xiaochen ; Huang, Wei; Xu, Chenjie*.  Fluorescent Poly (glycerol-co-sebacate)-acrylate Nanoparticles for Stem Cell Labeling and Longitudinal Tracking  ACS Applied Materials & Interfaces, 2017.
49) Tay, Li Min, Christian Wiraja, David C. Yeo, Yingnan Wu, Zheng Yang, Yon Jin Chuah, Eng Hin Lee, Yuejun Kang, and Chenjie Xu. Noninvasive Monitoring of Three-Dimensional Chondrogenic Constructs Using Molecular Beacon Nanosensors.  Tissue Engineering Part C: Methods, 2017, 23(1): 12-20.
48) Yang, Cangjie, Xiaochen Wang, Mingfeng Wang, Keming Xu, and Chenjie Xu.  Robust Colloidal Nanoparticles of Pyrrolopyrrole Cyanines J‐Aggregates with Bright Near Infrared Fluorescence in Aqueous Media: From Spectral Tailoring to Bioimaging Application. Chemistry-A European Journal, 2017.
47) Gao Y, Hassanbhai AM, Lim J, Wang L, Xu C, Fabrication of Silver Octahedral Nanoparticle-containing Polycaprolactone Nanocomposite for Antibacterial Bone Scaffolds. RSC Advances, 2017, 7, 10051-10056.
46) Mathiyazhakana M, Upputuri PK, Sivasubramanian K, Dhayani A, Vemula PK, Zou P, Pu K, Yang C, Pramanika M, Xu C, In Situ Synthesis of Gold Nanostars within Liposomes for Controlled Drug Release and Photoacoustic Imaging. SCIENCE CHINA Materials, 2016, doi:10.1007/s40843-016-5101-3 (cover).
45) Tay LM, Xu C*. Coating microbubbles with nanoparticles for medical imaging and drug delivery. Nanomedicine. 2017.
44) Fu J, Wiraja C, Chong R, Xu C*, Wang D*. Real-time and Non-invasive Monitoring of Embryonic Stem Cell Survival during the Development of Embryoid Bodies with Smart Nanosensor. Acta Biomaterialia, 2016.
43) Sivasubramanian K, Mathiyazhakan M, Wiraja C, Upputuri PK, Xu C*, Pramanik M*. Near Infrared light-responsive liposomal contrast agent for photoacoustic imaging and drug release applications Journal of Biomedical Optics 2016, 22(4), 041007.
42) Tay, H. M., Yeo, D. C., Wiraja, C., Xu, C., Hou, H. W. Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering. J. Vis. Exp. 2016, 113, e54327.
41) Wiraja C, Mathiyazhakan M, Movahedi F, Upputuri P.K, Cheng Y, Pramanik M, Yang L, Becker DL, Xu C*,  Near-infrared light-sensitive liposomes for enhanced plasmid 2 DNA transfection. Bioengineering & Translational Medicine, 2016, DOI 10.1002/btm2.10020.
40) Gao Y, Xu C*, Wang L*, Non-invasive monitoring of the osteogenic differentiation of human mesenchymal stem cells on the polycaprolactone scaffold using Raman imaging. RSC Adv., 2016, DOI: 10.1039/C6RA11636A
39) Hou X, Liu S, Wang M, Wiraja C, Huang W, Chan P, Tan T, Xu C*, Layer-by-Layer 3D constructs of fibroblasts in hydrogel for examining transdermal penetration capability of nanoparticles. Journal of Laboratory Automation, 2016, 1-7, DOI: 10.1177/2211068216655753
38) Xue P, Bao J, Zhang L, Xu Z, Xu C, Zhang Y, Kang Y, Functional magnetic Prussian blue nanoparticles for enhanced gene transfection and photothermal ablation of tumor cells. J. Mater. Chem. B, 2016, 4, 4717-4725
37) Liang K, Xu K, Bessarab D, Obaje J, Xu C*, Arbutin encapsulated micelles improved transdermal delivery and suppression of cellular melanin production, BMC Res Notes, 2016, 9:254
36) Zhu H, Fang Y, Zhen X, Wei N, Gao Y, Luo QK, Xu  C, Duan H, Ding D, Chen P, Pu K*, Multilayered Semiconducting Polymer Nanoparticles with Enhanced NIR Fluorescence for Molecular Imaging in Cells, Zebrafish and Mice, Chem. Sci., 2016, DOI: 10.1039/C6SC01251E
35) Li N, Than A, Wang X, Xu S, Sun L, Duan H, Xu CJ, Chen P*, Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots, ACS Nano, 2016, 10 (3), pp 3622–3629
34) Gao Y, Lim J, Yeo D, Liao S, Lans M, Wang Y, Teoh SH, Goh BT, Xu CJ*, A selective and purification-free strategy for labeling adherent cell with inorganic nanoparticles, ACS Applied Materials & Interfaces, 2016, 8(10):6336-43
33) Gao Y, Chan CU, Gu Q, Lin X, Zhang W, Yeo DCL, Alsema AM, Arora M, Chong MSK, Shi P, Ohl CD, Xu CJ*, Controlled nanoparticle release from stable magnetic microbubble oscillations, NPG Asia Materials, 2016, 8, e260
32) Karahan HE, Wei L, Goh K, Wiraja C, Liu Z, Xu CJ, Jiang R, Wei J, Chen Y. Synergism of Water Shock and a Biocompatible Block Copolymer Potentiates the Antibacterial Activity of Graphene Oxide. Small. 2016, 12(7):951-62.
31) Mathiyazhakan, M., Chan, W., Ohl, C. D., Xu, CJ*. Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation. J. Vis. Exp. 2016, 108, e53619.
30) Kumar N, Wiraja C, Palanisamy K, Marsili E, Xu CJ*,  Heat Shock Mediated Labelling of Pseudomonas aeruginosa with Quantum Dots, Colloids and Surfaces B: Biointerfaces, 2016, 142, 259-265
29) Wang M, Hou X, Wiraja C, Sun L, Xu Z, Xu CJ*. Smart Magnetic Nanosensors Synthesized through Layer-by-Layer Deposition of Molecular Beacons for Non-Invasive and Longitudinal Monitoring of Cellular mRNA, ACS Applied Materials & Interfaces, 2016, 8(9):5877-86
28) Gao Y, Lim J, Teoh SH, Xu CJ*.Cryomilling for the Fabrication of Doxorubicin-containing Silica-nanoparticle/polycaprolactone Nanocomposite Film, Nanoscale, 2016, 8(5):2568-74
27) Lio D, Yeo D, Xu CJ*, Control of alginate-core size in alginate-poly (lactic-co-glycolic) acid microparticles. Nanoscale Research Letters, 2016, 11(1), 1-6.
26) Wiraja C, Yeo D, Chong SK, Xu CJ*. Nanosensors for Continuous and Non-invasive Monitoring of Osteogenic Differentiation of Mesenchymal Stem Cells. Small, 2016, 12(10):1342-50
25) Shi W, Liu X, Chao W, Xu Z, Siong WSS, Liu L, Xu CJ*. Micro-Optical Coherence Tomography Tracking of Magnetic Gene Transfection via Au-Fe3O4 Dumbbell Nanoparticles. Nanoscale 2015, 7, 17249 – 17253
24) Yeo D, Wiraja C, Chuah YJ, Gao Y, Xu CJ*. A Nanoparticle-based Sensor Platform for Cell Tracking and Status/Function Assessment. Scientific Reports 2015, 5:14768 | DOI: 10.1038/srep14768
23) Yeo D, Wiraja C, Zhou Y, Tay H, Hou H, Xu CJ*. Interference-Free Micro/Nano-particle Cell Engineering Using High-Throughput Microfluidic Separation. ACS Applied Materials & Interfaces 2015, 7(37):20855-64
22) Lee Y*, Xu CJ*, Sebastin M, Lee A, Holwell N, Xu C, Miranda-Nieves D, Mu L, Langer R, Lin C, Karp JM. Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair. Advanced Healthcare Materials, 2015 Nov;4(16):2587-96 VIP (*Same Contribution)
21) Wiraja C, Yeo D, Chew SY, Xu CJ*.  Molecular Beacon-Loaded Polymeric Nanoparticles for Non-Invasive Imaging of mRNA Expression. Journal of Materials Chemistry B, 2015, 3, 6148 – 6156
20) Shi W, Wang VB, Zhao CE, Zhang Q, Loo SCJ, Yang L, Xu CJ*. Anditalea andensis ANESC-ST – An alkaliphilic halotolerant bacterium capable of electricity generation under alkaline–saline conditions. PLoS ONE, 2015, 10(7):e0132766.
19) Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun SH, Teoh SH, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu CJ*. Accelerating the Translation of Nanomaterials in Biomedicine. ACS Nano, 2015, 9 (7), 6644–6654
18) Gao Y, Lim J, Teoh SH, Xu CJ* Emerging translational research on magnetic nanoparticles for regenerative medicine Chem. Soc. Rev., 2015, 44, 6306 – 6329
17) Gao Y, Tan KM, Li Y, Minn KT, Alsema AM, Xu CJ*. Characterization of Titanium Dioxide Nanoparticles on Porcine Skin by Raman Microscopy. Analytical Letters 2015, 48:15, 2391-2399
16) Chilla GS, Tan CH, Xu CJ*, Poh CL. Diffusion weighted magnetic resonance imaging and its recent trend—a survey Quantitative Imaging in Medicine and Surgery. (2015), 5(3): 407-422.
15) Movahedi F, Hu G, Becker DL, Xu CJ*. Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics. Nanomedicine: Nanotechnology, Biology, and Medicine 2015, 11(6), 1575-1584
14) Gao Y, Wang Y, Fu A, Shi W, Yeo D, Kolachina M, Luo KQ, Ow H, Xu CJ*. Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles. Journal Materials Chemistry B 2015, 3, 1245-1253
13) Mathiyazhakan M, Yang Y, Liu Y, Zhu C, Liu Q, Ohl CD, Tam KC, Gao Y, Xu CJ*. Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation. Colloids Surf. B: Biointerfaces 2015, 126, 569–574
12) Wiraja C, Yeo DC, Lio D, Labanieh L, Lu M, Zhao W, Xu CJ*. Aptamer technology for tracking cells: status & function. Molecular and Cellular Therapies 2014, 2:33
11) Liu Y, Loh W, Ananthanarayanan A., Yang C, Chen P, Xu CJ*. Fluorescence quenching between unbonded graphene quantum dots and gold nanoparticles upon simple mixing. RSC Advances 2014, 4: 35673 – 35677
10) Yeo DC, Wiraja C, Mantalaris A, Xu CJ*. Nanosensors for Regenerative Medicine.  Journal of Biomedical Nanotechnology.  2014; 10: 2722–2746
9) Xue P, Yeo DCL, Chuah YJ, Kang YJ, Xu CJ*.  Drug-eluting Microneedles for the Self-management of Keloids. Technology. 2014; 2(2): 144-152
8) Vemula P, Kohler JE, Blass A, Williams M, Xu CJ, Chen L, Jadhav SR, John G, Soybel DI, Karp JM.  Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu. Scientific Reports. 2014; 4:4466
7) Lang N, Pereira MJ, Friehs I, Vasilyev N, Feins E, Ablasser K, O’Cearbhaill E, Xu CJ, Fabozzo A , Lee Y, Padera R, Wasserman S, Freudenthal F , Ferreira L, Langer R, Karp JM, del Nido PJ. A biocompatible light-activated adhesive for minimally invasive repair of cardiovascular defects. Science Translational Medicine. 6, 218ra6 (2014) [Cover]
6) Ankrum J, Miranda O, Ng K, Sarkar D, Xu CJ, Karp JM. Engineering cells with intracellular agent–loaded microparticles to control cell phenotype.  Nature Protocols. 2014; 9(2), 233-245
5) Liu Y, Gao Y, Xu CJ*. Using magnetic nanoparticles to manipulate biological objects. Chinese Physics B. 2013; 22(9):097503
4) Xu CJ*, Zhao W. Nanoparticle-based Monitoring of Stem Cell Therapy. Theranostics 2013; 3(8):616-617
3) Eckert MA, Vu PQ, Zhang K, Kang D, Ali MM, Xu CJ. Zhao W. Novel Molecular And Nanosensors For In Vivo Sensing. Theranostics. 2013;3(8):583-594
2) Wang Y, Xu CJ*, Ow H. Commercial nanoparticles for Stem cell labeling and Tracking. Theranostics. 2013; 3(8):544-560
1) Gao Y, Cui Y, Chan JKY, Xu CJ*. Stem cell tracking with optically active nanoparticles. Am J Nucl Med Mol Imaging 2013; 3(3):232-246.

Scientific Publications (Before 2012)



5) Wang M, Marepally SK, Vemula PK*, Xu CJ*, Chapter: “Inorganic nanoparticles for transdermal drug delivery and topical application”. Nanoscience and Dermatology, edited by Michael Hamblin, Pinar Avci, and Tarl Prow, 2016, published by Academic Press.
4) Perspectives in Micro- and Nanotechnology for Biomedical Applications. Edited by Juliana M. Chan and Chenjie Xu. 2016, World Scientific Publishing and Imperial College Press
3) Yeo DC, Minocha R, Xu CJ*, Chapter 11: “Cell Engineering with Nanoparticles for Cell Imaging”. Micro-and nanoengineering of the cell surface. Edited by Jeffrey Karp and Weian Zhao. Elsevier Inc. 2014
2) Gao Y, Liu Y, Xu CJ*. Chapter 21: “Magnetic nanoparticles for biomedical applications: from diagnosis to treatment to regeneration”. Engineering in Translational Medicine. Edited by Weibo Cai. Springer, 2014
1) Wang C, Xu CJ* Chapter 2: “Design, Synthesis and Application of Dumbbell-like Nanoparticles”. Janus particle synthesis, self-assembly and applications. Edited by Shan Jiang and Steve Granick. Royal Society of Chemistry, 2012



5) Karp JM, Lee Y, Xu CJ, Langer RS, Miranda-Nieves D. Bio-Inspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair. July 16, 2015. U.S. Application No.: 62/193158
4) Xu CJ, Shi W, Yang L. Fouling Green Technology. August 25th, 2014. Filing number: 10201405191U; NTU Ref: PAT/104/14/14/SG PRV
3) Xu CJ, Kang YJ, Yeo DC, Xue P. Microneedles for Keloid Management. August 1st, 2013. Filing number: 61/861,117
2) Xu CJ, Sun S. Au-like-Fe3O4 Nanoparticles for Antibody-Conserving Target-Specific Platin Delivery. WO 201103147
1) Rao J, Loening AM, Gambhir SS, So MK, Xu CJ. Self-illuminating quantum dot systems and methods of use for detecting targets in biological systems and disease diagnosis.PCT Int. Appl. (2007), WO  2007081716  A2  20070719