Full list of publication:

Selected representative publications on the topic of

6) Others

  • Lio DCS, Chia RN, Kwek MSY, Wiraja C, Madden LE, Chang H, Khadir SMA, Wang X*, Becker DL*, Xu C*. Temporal Pressure Enhanced Topical Drug Delivery through Micropore Formation. Science Advances. 2020, 6(22), eaaz6919

5) Cell delivery

  • Huaxin Yang, Mengjia Zheng, Yuyue Zhang, Chaochang Li, Joseph Ho Chi Lai, Qizheng Zhang, Kannie WY Chan, Hao Wang, Xin Zhao, Zijiang Yang*, Chenjie Xu*. Enhanced angiogenesis in porous poly (ε-caprolactone) scaffolds fortified with methacrylated hyaluronic acid hydrogel after subcutaneous transplantation. Biomaterials Translational, 2024, 5(1): 59

4) Nucleic acid-based nanoparticles

  • Han Y, et al. Topical Delivery of microRNA-125b by Framework Nucleic Acids for Psoriasis Treatment. International Journal of Nanomedicine, 2024: 2625-2638.
  • Xu J, et al. NanoBeacon. AI: AI-enhanced nanodiamond biosensor for automated sensitivity prediction to oxidative phosphorylation inhibitors. ACS Sensors, 2023, 8(5): 1989-1999.
  • J Hwang, Y Seo, D Jeong, X Ning, C Wiraja, L Yang, CT Tan, J Lee, Y Kim, JW Kim, DH Kim, J Choi, CY Lim, K Pu, WY Jang, C Xu*. Monitoring Wound Healing with Topically Applied Optical NanoFlare mRNA Nanosensors. Advanced Science, 2022, 2104835.
  • C Wiraja, Y Mori, T Ichimura, J Hwang, C Xu*, JV Bonventre*. Nephrotoxicity Assessment with Human Kidney Tubuloids using Spherical Nucleic Acid-Based mRNA Nanoflares. Nano Letters. 2021, 21 (13), 5850–5858.
  • Ponedal A, Zhu S, Sprangers A, Wang XQ, Yeo DC, Lio D, Zheng M, Capek M, Narayan S, Meckes B, Paller A*, Xu C*, Mirkin C*. Attenuation of abnormal scarring using spherical nucleic acids targeting transforming growth factor beta 1. ACS Applied Bio Materials 2020, 3(12), 8603.
  • Tanner EEL, Wiraja C, Curreri CA, Xu C*, Mitragotri S*. Stabilization and Topical Skin Delivery of Framework Nucleic Acids using Ionic Liquids. Advanced Therapeutics. 2020, 3(7), 2000041
  • Wiraja C, Zhu Y, Lio D, Yeo DC, Xie M, Fang W, Li Q, Zheng M, Van Steensel M, Wang L, Fan C*, Xu C*. Framework Nucleic Acids as Programmable Carrier for Transdermal Drug Delivery. Nature Communication, 2019, 10, 1147
  • Yeo DC, Wiraja C, Paller AS*, Mirkin CA*, Xu C*. Abnormal Scar Identification with Spherical Nucleic Acids Technology, Nature Biomedical Engineering, 2018, 2, 227

3) Microneedles

  • Zheng M, et al. Microneedle biomedical devices. Nature Reviews Bioengineering, 2023: 1-19.
  • Zheng M, et al. In situ-formed cryomicroneedles for intradermal cell delivery. NPG Asia Materials, 2024, 16(1): 11.
  • Wang G, et al. On‐Site Melanoma Diagnosis Utilizing a Swellable Microneedle‐Assisted Skin Interstitial Fluid Sampling and a Microfluidic Particle Dam for Visual Quantification of S100A1. Advanced Science, 2024: 2306188.
  • Chang H, et al. Co‐delivery of dendritic cell vaccine and anti‐PD‐1 antibody with cryomicroneedles for combinational immunotherapy. Bioengineering & Translational Medicine, 2023, 8(5): e10457.
  • Zheng M, et al. A skin patch integrating swellable microneedles and electrochemical test strips for glucose and alcohol measurement in skin interstitial fluid. Bioengineering & Translational Medicine, 2023, 8(5): e10413.
  • Zhang Y, et al. A nanometallic conductive composite-hydrogel core–shell microneedle skin patch for real-time monitoring of interstitial glucose levels. Nanoscale, 2023, 15(40): 16493-16500.
  • Yu J, et al. Intradermal delivery of mRNA using cryomicroneedles. Acta Biomaterialia, 2022, 148: 133-141.
  • Y Huang, et al. Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery. Nano Letters 2022 22 (14), 5944-5953
  • Hu T, et al. Transdermal delivery of dextran using conductive microneedles assisted by iontophoresis. Journal of Materials Chemistry B, 2022, 10(39): 8075-8081.
  • F Leng, M Zheng, C Xu*. 3D printed microneedles with open groove channels for liquid extraction, Exploration, 2021, 1 (3), 20210109.
  • X Ning, S Chen, Y Yang, J Hwang, C Wiraja, C Zhang, W Liu, L Liu, C Xu*. Photodynamic Bubble-Generating Microneedles for Enhanced Transdermal Cancer Therapy. ACS Applied Polymer Materials, 2021, 3 (12), 6502-6512.
  • X Ning, C Wiraja, WTS Chew, C Fan, C Xu*. Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment. Acta Pharmaceutica Sinica B, 2021, 11 (9), 2937-2944.
  • RZ. Seeni, DCS Lio, C Wiraja, MFB Yusoff, WTY Koh, Y Liu, BT Goh*, C Xu*. Targeted Delivery of Anaesthetic Agents to Bone Tissues using Conductive Microneedles Enhanced Iontophoresis for Painless Dental Anaesthesia. Advanced Functional Materials, 2021, 31(47), 2105686. 
  • M Cui, M Zheng, C Wiraja, SWT Chew, A Mishra, V Mayandi, R Lakshminarayanan*, C Xu*. Ocular delivery of predatory bacteria with cryo-microneedles against eye infection. Advanced Science, 2021, 8(21), 2102327.
  • C Kuwentrai, J Yu, L Rong, B-Z Zhang, Y-F Hu, H-R Gong, Y Dou, J Deng, J-D Huang*, C Xu*. Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice. Bioengineering & Translational Medicine, 2021, 6, e10202.
  • H Chang, SWT Chew, M Zheng, DCS Lio, C Wiraja, Y Mei, X Ning, M Cui, A Than, P Shi, D Wang, K Pu, P Chen, H Liu, C Xu*. Cryomicroneedles for Transdermal Cell Delivery. Nature Biomedical Engineering, 2021, 5, 1008–1018.
  • Ning X, Wiraja C, Lio DCS, Xu C*. A double layered microneedle platform fabricated through frozen spray-coating. Adv. Healthcare Mater. 2020, 9(10), 2000147.
  • M Zheng, Z Wang, H Chang, L Wang, SWT Chew, DCS Lio, M Cui, L Liu, BCK Tee,* C Xu*. Osmosis-Powered Hydrogel Microneedles for Microliters of Skin Interstitial Fluid Extraction within Minutes. Adv. Healthcare Mater. 2020, 1901683.
  • Than A, Liu C, Chang H, Duong PK, Wang X*, Xu C*, Chen P*. Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery, Nature Communication, 2018, 9, 4433.
  • Than A, Liang K, Xu S, Sun L, Duan H, Xi F, Xu C*, Chen P*. Obesity compounds to subcutaneous adipose tissue with polymeric microneedles patches. Small Methods. 2017, 1, 1700269.
  • Chang H, Zheng M, Yu X, Than A, Seeni RZ, Kang R, Tian J, Khanh DP, Liu L, Chen P*, Xu C*. A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis. Advanced Materials. 2017, 29 (37), 1702243.
  • Tan C, Yeo D, Cao T, Tan VW, Srivastava R, Yow AP, Tan WP, Wong DW, Xu C, Tey HL*. Drug‐free microneedles in the treatment of keloids: a single‐blinded intra‐individual controlled clinical trial. Br J Dermatol. 2018, 179(6), 1418.
  • Yeo D, Balmayor E, Schantz JT, Xu C*. Microneedle Physical Contact as a Therapeutic for Abnormal Scars. European Journal of Medical Research, 2017, 22(1): 28.
  • Xue P, Yeo DCL, Chuah YJ, Kang YJ, Xu C*. Drug-eluting Microneedles for the Self-management of Keloids. Technology. 2014; 2(2): 144.

2) Stem cell tracking

  • Wiraja C, Yeo DC, Tham KC, Chew SWT, Lim X, Xu C*. Real-Time Imaging of Dynamic Cell Reprogramming with Nanosensors, Small, 2018, 14, 1703440.
  • Fu J, Wiraja C, Chong R, Xu C*, Wang D*. Real-time and Non-invasive Monitoring of Embryonic Stem Cell Survival during the Development of Embryoid Bodies with Smart Nanosensor. Acta Biomaterialia, 2017, 49, 358–367
  • Pan J, Wiraja C, Zhao J, Zhang J, Li M, Zheng L, Xu C*. Nitric oxide nanosensors for predicting the development of osteoarthritis in rat model, ACS Applied Materials & Interfaces, 2017, 9(30), 25128-25137.
  • Gao Y, Lim J, Yeo D, Liao S, Lans M, Wang Y, Teoh SH, Goh BT, Xu C*, A selective and purification-free strategy for labeling adherent cell with inorganic nanoparticles, ACS Applied Materials & Interfaces, 2016, 8(10):6336
  • Wiraja C, Yeo D, Chong SK, Xu C*. Nanosensors for Continuous and Noninvasive Monitoring of Mesenchymal Stem Cell Osteogenic Differentiation. Small, 2016, 12(10):1342
  • Xu C, Miranda-Nieves D, Ankum J.A., Matthiesen M.E., Philips J.A., Roes I, Wojtkiewicz GR, Kultima JR, Zhao W, Vemular PK, Lin CP, Nahrendorf M., Karp JM*. Tracking Mesenchymal Stem Cells with Iron Oxide Nanoparticles Loaded Poly(lactide-co-glycolide) Microparticles. Nano Letters, 2012, 12(8):4131

1) Magnetic nanoparticles

  • Wang S, Guo X, Xiu W, Liu Y, Ren L, Xiao H, Yang F, Gao Y*, Xu CJ, Wang L*. Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles. Science advances 2020, 6(31): eaaz8204
  • Gao Y, Chan CU, Gu Q, Lin X, Zhang W, Yeo DCL, Alsema AM, Arora M, Chong MSK, Shi P, Ohl CD*, Xu CJ*, Controlled nanoparticle release from stable magnetic microbubble oscillations, NPG Asia Materials, 2016, 8, e260
  • Xu CJ, Yuan ZL, Kohler N, Kim JM, Chung MA, Sun SH*. FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition. Journal of the American Chemical Society, 2009, 131(42): 15346
  • Xu CJ, Wang BD, Sun SH*. Dumbbell-like Au-Fe3O4 Nanoparticles for Target-Specific Platin Delivery. Journal of the American Chemical Society, 2009, 131(12): 4216
  • Xu CJ, Tung GA, Sun SH*. Size and Concentration Effect of Gold Nanoparticles on X-ray Attenuation As Measured on Computed Tomography. Chemistry of Materials, 2008, 20(13): 4167
  • Xu CJ, Xie J, Don H, Wang C, Kohler N, Walsh E, Morgan J, Chin YE, Sun SH*. Au-Fe3O4 Dumbbell Nanoparticles as Dual-Functional Probes. Angewandte Chemie International Edition, 2008, 47: 173
  • So MK#, Xu CJ#, Loening AM, Gambhir SS, Rao JH*. Self-illuminating quantum dot conjugates for in vivo imaging. Nature Biotechnology, 2006, 24(3): 339 (#Same Contribution)
  • Xu CJ, Xu K, Gu HW, Zheng RK, Liu H, Zhang XX, Guo Z, Xu B*. Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. Journal of the American Chemical Society, 2004, 126(32): 9938
  • Xu CJ, Xu K, Gu HW, Zhong X, Guo Z, Zheng RK, Zhang XX, Xu B*.  Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins. Journal of the American Chemical Society, 2004, 126(11): 3392